The Role Of The Gastrointestinal Tract And Diabetes Mellitus

Introduction: This study examines the ATP binding cassette transporters, ABCA1 and ABCG1 and their presence in the small intestines (GI tract) during a chronic inflammatory disease, diabetes mellitus (type 2 diabetes). ABCA1 and G1 are important in the regulation of glucose levels in the blood in the small intestine when type 2 diabetes is present. The relationship of the gastrointestinal tract and diabetes mellitus has become increasingly important in the scientific community. The GI tract plays a key role in glucose homeostasis. The GI tract becomes inflamed in the presence of diabetes mellitus causing various complications. ABCA1 and ABCG1 play important parts in glucose homeostasis, insulin secretion, and cell survival. However, these transporter proteins, in normal conditions, are overshadowed by other molecules with similar functions. Interestingly, ABCA1 and ABCG1 have inflammatory functions as well. Type 2 diabetes is an inflammatory disease. If ABCA1 and ABCG1 are increased in an inflamed intestine, as in the case of diabetes mellitus, then these molecules are a direct alteration from this disease because these molecules have anti-inflammatory functions and the inflammation of the intestine is a primary cause. Before the study was done, the researchers needed to have a significant understanding of diabetes mellitus: How a patient could obtain this disease, and how to actually diagnose this disease and not mistake it for type 1 diabetes. They obtained otherShow MoreRelatedInternational Conference On Harmonization Guidelines1612 Words   |  7 Pagesis available in Canada as Apo-Metformin but Vildagliptin (Glavus) is not available in Canada and is needed to shipping from US under the Health Canada Regulations (Part C, Division 5). 1.1 Background Diabetes mellitus is a common diseases in the world and Canada is diabetes mellitus. Diabetes Mellitus has been starting to grow all over the world. 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